How to study for this course…
Chapter 1
Introduction &
Homeostasis
• Overall
– Make your own flow charts, tables, diagrams, sketches, etc to organize the material
– Watch videos & animations
– Learn prefixes & terms by making flashcards, charts or lists
– Make connections among the systems
• Lecture
– Review lecture slides & notes…within 24 hours after presentation
– Preview the material in the chapter that corresponds to the lecture
– Look at the diagrams
– Skim introductory sections and paragraphs
– Learn the bolded terms
© 2013 Pearson Education, Inc.
• Lab
– Pre-read & study background information of each lab before class
– Review post-lab questions and think about reasoning behind each procedure…within 24 hours after that lab
Table 1.2 Biology Concepts
Overview
Common Themes in Physiology
(all below excluding evolution)
• Why do we say physiology is an integrative science?
• Common themes:
– Structure => Function
– Homeostasis
– Regulation: Change => Feedback
© 2013 Pearson Education, Inc.
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Figure 1.1 Levels of organization and the related fields of study
Levels of Organization
• Physiology defined
– Study of the normal functioning of a living organism and its component parts
– Our scope: Human & Normal/Ideal function
– But we will often use pathophysiology to understand and explain normal physiology
– Greek root “pathos” = suffering/disease
PHYSIOLOGY
ECOLOGY
CELL
MOLECULAR BIOLOGY
CHEMISTRY BIOLOGY
Atoms
Molecules
Cells
Tissues
Organs
Organ systems Populations of one species
Organisms
Ecosystem of different species
Biosphere
• How we define life…The cell theory!
– The cell is the basic unit of life.
– All cells originate form pre-existing cells.
– All living organisms are composed of cells.
© 2013 Pearson Education, Inc.
Table 1.1 Organ Systems of the Human Body and their Integration
Figure 1.3 Homeostasis
Homeostasis
• Regulation of the body s internal environment • Keeping internal environment stable & near a set-point or optimal level
Organism in homeostasis Internal change External change Internal change results in loss of homeostasis
Organism attempts to compensate
Compensation fails
Compensation succeeds
Illness or disease
Wellness
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Figure 1.4 The body s internal and external environments
Example:
Body Fluid Compartments
Cells contain intracellular fluid (ICF)
The cell membrane separates cells from the ECF
¼ plasma
Cells
ECF
External environment Extracellular fluid (ECF)
Intracellular fluid (ICF)
Cells are surrounded by the extracellular fluid (ECF)
ECF
1/3 TBF
ICF
2/3 TBF
¾ interstitial fluid FIGURE QUESTION
Put a * on the cell membrane of the box diagram.
TBF = total body fluid
ECF =
ICF =
Figure 1.5 Mass balance in an open system
Homeostasis
Both below represent when homeostasis is achieved.
Input
To maintain constant level, output must equal input.
Input
Output
Intake through intestine, lungs, skin
Excretion by kidneys, liver, lungs, skin
BODY
LOAD
Metabolic production Metabolism to a new substance Output
Mass balance in an open system
Mass balance =
Existing + body load
Mass balance in the body
• constant input of energy is required to maintain stability (due to the use)
• Increases order & decreases entropy of that system
Equilibrium
• input is NOT continuously required (no net difference in energy input/output)
• entropy differences dissipate by balancing out
VS
Law of Mass Balance
Intake or metabolic production
Steady State
-
Excretion or metabolic removal
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Figure 1.9 Steps in the response loop of a reflex control pathway
Reflex steps