Acetylcholine And Physostigmine Research Paper

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Acetylcholine and physostigmine
Physostigmine inhibits the metabolism of acetylcholine and indirectly stimulates nicotinic and muscarinic receptors
As acetylcholine is not broken down/metabolised, physostigmine increases the concentration of acetylcholine at the sites of the cholinergic transmission.
2. List the interactions where a decrease in the agonist’s effect is seen, and for each one briefly explain why there is a decrease.
Acetylcholine and Promethazine
Promethazine acts as an anticholinergic drug by binding to the muscarinic receptors and inhibiting the responses of acetylcholine.

Histamine and Promethazine
Promethazine is an antihistamine that blocks the central and peripheral effects of histamine on the histamine H1 receptors. Therefore, …show more content…
Muscle contractions are unable occur due to the relaxation of muscle.
Acetylcholine and Atropine
Atropine is an antimuscarinic drug that inhibits acetylcholine from binding to muscarinic acetylcholine receptors, and therefore muscarinic behaviour is not induced by acetylcholine.
DMPP, Angiotensin and Atropine
Atropine causes acetylcholine to be released at the postsynaptic terminal, but blocks the release of acetylcholine at the neuromuscular junctions.
DMPP and Hexamethonium
Hexamethonium is a nicotinic antagonist that blocks DMPP as they compete for binding sites, thus the activity of DMPP is reduced.

3. Identity of unknown: Angiotensin (Agonist)
Method used for identification: The unknown drug was placed into the ileum preparation at a concentration of 3 uM, which produced a response of approximately 60 mm. This peak illustrates that the unknown drug was an agonist. The antagonists: atropine (0.3 uM), physostigmine (1 uM), mepyramine (0.3 uM), promethazine (0.3 uM), papaverine (1 uM) and hexamethonium (1 uM) were used for the identification of the unknown agonist. Each antagonist was added prior to adding the unknown agonist into the preparation and was washed out after a response was
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