This type of pain research has been under extensive investigation for the last decade aiming to identify an understanding for pain. Genetic linkage of pain in a humans family explains why some families can withstand certain temperatures and conditions; their generations have always been able to cope. The family tree has adapted to where there is no difference between a hot day in Texas to a scolding day in the Sahara. Specific pain disorders may also cause diverse feeling of pain. Primary erythromelalgia (PE) is an autosomal dominant disorder with symptoms typically including episodes of burning pain triggered by heat or exercise. Congenital insensitivity to pain (CIP) is autosomal recessive and extremely rare disorder. People with this disorder to not feel nor have ever felt physical pain. Congenital insensitivity to pain with anhidrosis (CIPA) is an extremely rare inherited disorder of the nervous system which prevents the sensation of pain, heat, cold, or any real nerve-related sensations. This disorder is apart of a group of disorders that consist of five types of hereditary sensory neuropathies (HSNs) characterized by sensory loss, insensitivity to pain, and a variable degree of muscle weakness and wasting, as well as autonomic features. Inheritance may play a significant role in human pain, though most of pain disorders are triggered by known or not identified environmental factors. Chronic pain provides the best reasoning of the interaction between nature and nurture when it comes to