a) coined the term chemotherapy
b) discovered salvarsan in 1910
c) discovered the antibiotic streptomycin
d) accomplished two of the above.
Answer: d
Difficulty: Medium
Learning Objective 1: LO 13.1 Review the contributions to chemotherapy made by Ehrlich, Domagk, Fleming, and Florey.
Section Reference 1: Section 13.1 Antimicrobial Chemotherapy
2) Penicillin was discovered by ____________ and was isolated by ________ .
a) Gerhard Domagk; Alexander Fleming
b) Selman Walksman; Ernest Fourneau and Paul Ehrlich
c) Ernst Chain and Howard Florey; Paul Ehrlich
d) Alexander Fleming; Ernst Chain and Howard Florey
Answer: d
Difficulty: Medium
Learning Objective 1: LO 13.1 Review the contributions to chemotherapy made by Ehrlich, Domagk, Fleming, and Florey.
Section Reference 1: Section 13.2 The History of Chemotherapy
3) Any chemical substance used in medical practice is known as a/an:
a) antibiotic
b) antimicrobial agent
c) semi-synthetic drug
d) chemotherapeutic agent
Answer: d
Difficulty: Easy
Learning Objective 1: LO 13.1 Review the contributions to chemotherapy made by Ehrlich, Domagk, Fleming, and Florey.
Section Reference 1: Section 13.1 Antimicrobial Chemotherapy
4) A special group of chemical substances that are used to treat diseases caused by microbes are called _____.
a) antibiotics
b) synthetic drugs
c) semi-synthetic drugs
d) antimicrobial agents
Answer: d
Difficulty: Easy
Learning Objective 1: LO 13.1 Review the contributions to chemotherapy made by Ehrlich, Domagk, Fleming, and Florey.
Section Reference 1: Section 13.1 Antimicrobial Chemotherapy
5) Selective toxicity:
a) harms the microbes without significantly harming the host.
b) causes host damage without causing significant damage to the microbe.
c) is the maximum tolerable dose of a drug per kilogram of body weight.
d) is the same as the spectrum of activity for any given drug.
Answer: a
Difficulty: Easy
Learning Objective 1: LO 13.2 Report mechanisms of action by which antimicrobial agents may work, possible ways in which they may exert toxic side effects, and ways in which drug resistance may develop.
Section Reference 1: Section 13.3 General Properties of Antimicrobial Agents
6) The mode of action of an antimicrobial agent refers to _____.
a) killing of all microorganisms.
b) inhibition of growth of bacteria.
c) how it exerts its effects upon microorganisms.
d) the broad spectrum of activity of the antimicrobial agent.
Answer: c
Difficulty: Medium
Learning Objective 1: LO 13.2 Report mechanisms of action by which antimicrobial agents may work, possible ways in which they may exert toxic side effects, and ways in which drug resistance may develop.
Section Reference 1: Section 13.3 General Properties of Antimicrobial Agents
7) Which of the following is not considered a mode of action by antimicrobial agents?
a) Inhibition of protein synthesis.
b) Inhibition of cell wall synthesis.
c) Inhibition of membrane permeability.
d) Disruption of selective toxicity.
Answer: d
Difficulty: Medium
Learning Objective 1: LO 13.2 Report mechanisms of action by which antimicrobial agents may work, possible ways in which they may exert toxic side effects, and ways in which drug resistance may develop.
Section Reference 1: Section 13.3 General Properties of Antimicrobial Agents
8) Which of the following directly pertain to inhibition of cellular protein synthesis by antimicrobial agents?
a) cellular cytoplasm is lost
b) binding and inhibition of RNA polymerase
c) imitation or molecular mimicry of normal molecules
d) interferes with accurate translation of mRNA message
Answer: d
Difficulty: Medium
Learning Objective 1: LO 13.2 Report mechanisms of action by which antimicrobial agents may work, possible ways in which they may exert toxic side effects, and ways in which drug resistance may develop.
Section Reference 1: Section 13.3 General
