Research points to actual muscle cell damage, when muscles feel sore, and an elevated release of various metabolites into the tissue surrounding the muscle cells. These responses to intense exercise result in an inflammatory-repair response which may lead to swelling and soreness after the exercising. When a muscle lengthens against a load the muscle contraction is supposedly eccentric. This may result in more muscle cell damage than is seen in concentric contractions, in which a muscle successfully shortens during contraction against a load. In conclusion, exercises with the most muscle contractions, such as downhill running, result in the most DOMS, or muscle soreness. There are many anti-inflammatory medicines that solve the short term problem, but can possible harm the muscles by slowing down the time it takes