Compare and Contrast Of Mice and Men/One Flew Over the Cuckoo’s Nest Both Of Mice and Men and One Flew Over the Cuckoo’s Nest share many similarities like the isolation of the characters, the freedom and confinement of them both mentally and physically, and the effect women have on the male characters. Though these themes have much in common in both stories, but there are some major differences. Some are in the details of how the characters deal with those problems; others are in how it all ends and why. Starting off is the theme of women. In both stories, the women are what cause the characters and specifically the male characters their plights. In Of Mice and Men, George and Lennie has a problem with women from the start. Lennie grabs