Early in life, there is a sense of understanding of how to deal with issues of loss or rejection, but being in the state of depression may alter the ability to know how to deal with these issues. Stressful life events that may trigger a change in mood of those suffering from depression may be the death of a loved one, rejection of a job, or a significant relationship that has been disturbed. Stress is significant to the development of depression. In relation to the body’s system falters, adding stress will cause lifelong changes to the body and brain. Stress hormones will produce physiological changes. Corticotropin-releasing hormone, also known as cortisol, will be released when the hippocampus responds to stress, and it will affect the amygdala to change a person’s mood and behavior (Harvard