Dopamine Receptor Lab Report

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Azarya Tafesse
Scientific Communication
Date Due: Friday November 6th 2015
Seminar-Summary Assignment by Dr. Huang Phylogenetic Analysis of Metabotropic Glutamate Receptors and Dopamine Receptors
Research Background Glutamate is a neurotransmitter prevalent in CNS. While glutamate uses inotropic and metabotropic glutamate receptors (mGluRs), this study is exclusive to metabotropic glutamate receptors. Metabotropic glutamate receptors are seven-transmembrane proteins coupled that are activated by the binding of glutamate. As discussed in BCMB activation is a result of an attached GDP molecule being replaced by a GTP molecule. The activation of mGluRs leads to a second messenger cascade which allows the signal to be amplified and expedited. …show more content…
Dopamine Dopamine binds to a G protein coupled, transmembrane receptor. The binding of Dopamine activates a cascade a second messenger cascade resulting in various short term responses and gene transcription {{Yamamoto,Kei 2013;}}. The 5 subtypes of Dopamine receptors are labelled D1-D5. This study investigates the phylogenetic development of mGluRs and dopamine receptors in different animals, it attempts to answer the question: how are mGluRs and dopamine receptors phylogenetically related in different animals? While the differences between mGluRs and dopamine receptors is documented the specific evolutionary relation of the receptors among these species is not …show more content…
In addition there was a closer phylogenetic relation between mouse and humans for corresponding receptor subtypes than with different subtypes in the same organism (for example, mGluR1 subtype in humans is more similar to mice mGluR1 subtype than another subtype in human). The phylogenetic tree for dopamine receptors similarly implies the mouse receptor to be most similar that of humans. However there seems to be more amino acid variation in the dopamine receptors compared to mGluRs (assuming both images shown were in the same

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