FACTS
ACTION
INDICATION
CONTRA -INDICATION
ADVERSE EFFECT
INTERACTION
NURSING IMPLICATION
ANAESTHETICS
*GENERAL
-↓LOC
*LOCAL/REGIONAL
-specific area
-no ↓LOC
*Types:
-inhaled
-injectable-IV
-balanced-combi
*Types:
-topical
-parenteral IV/CNS spinal inject
(-caine) lidocaine
-central intrathecal/epidural
-peripheral nerve block
* ↓ CNS funxn / sensory
*Overton-Meyer Theory
↑fat solubility = ↑effect
*NEUROMUSCULAR BLOCKING DRUGS
-muscle paralysis
- (+)mechvent- d/t respi paralysis
- (+)paralyze, Conscious
-controlled ventilation during surgical procedure
-Diagnostic drug: Myasthenia G.
*MODERATE SEDATION
-conscious/procedural sedation
-IV benzodiazepine + opiate
-↓pt’s anxiety, mem of procedure
-for dx procedure
-rapid recovery time
*surgical procdre
-rapid onset
*surgical, dental, diagnostic
*drug allergy
*pregnancy
*glaucoma
*ophthalmic use
*drug allergy
*myocardial depression
*malignant hyperthermia (>40c)
*paralysis
Auto-Sensory-Motor (onset)
Motor-Sensory-Auto (recovery)
*spinal headache
Treat: epidural blood patch
*drug-to-drug:
-antihypertensives
-b-blockers
-tetracyclines
*epinephrine,
Bupicavaine, etc
=>dysrthymias
*assess:
-hx of surgeries
-allergies, meds
-alcohol use, illicit drugs
-VS (intra, peri, post)
-ABCs
-watchout ↑Temp
-re orient
-pre-op teaching
Postop turning, coughing,
Deep breathing
-NMBAs: Pt paralyzed, but awake
ANTIANXIETY
-tx mental, emotional health disorders
*ANXIETY
-neurotransmitter imbalance
>CATECHOLAMINES
Dopa. norEpi
>INDOLAMINES
Serotonin, Histamine
*Types:
-Benzodiazipines
(-lam/-pam) diazepam
-Antihistamine
-MIsc: BuSpar
*BARBITURATES CARBAMATES
- prev used to tx anxiety
-↓Brainstem, Limbic actv
-↓CNS sedation, allergc
-non-sedating
*anxiety
*sedation
*seizure control
*adjuvant:depress
*alcohol withdrwl
*sedatives
*alcohol=FATAL
*↓CNS activities
*hypotension
*drowsiness
*N/V
FLUMAZENIL
-txt benzo overdose
*assess:
-phx and emo state
-baseline VS –posturalBP
-LOC
-position slowly-postural hypotension and injury
-drug+psycho tx= effctiv
-alcohol=FATAL
-therapeutic effect:
Mental alertness
SEDATIVES and
HYPNOTICS
-CNS depressants
*SEDATIVE-HYPNOTICS- DOSE DEPENDENT
-↓dose= (-)sleep
-↑dose= (+) Sleep
•SEDATIVES
•HYPNOTICS
*Types:
-Barbiturates
(-bital) phenobarbital
-↓nervousness, ↓ excitability (-) SLEEP
-(+) SLEEP
-↓nerve impulse to cerebral cortex
-act on BrainStem primarily
*txt insomnia => sedation
*↓dose=sedative
*↑dose=hypnotic
*enzyme inducer
(liver enzyme to breakdown drugs)
*sedative
*hypnotic
*anticonvulsant
*anesthesia-surg
*respi difficulty
*severe liver dse
*REM (rapideyemovt) rebound –d/t discontinuing txt
*CNS-drowsiness, lethargy
*Respi- Res dpresn, apnea
*GI-N/V, diarrhea, consti
*Other-StevenJohnson Syn
*REM=>agitation
*TOXCITY/OVRDOSE
-respi arrest
-coma=>death
*↑CNS depression
*Inhibit metabolism -MAOIs prolong effects of barbirurates
*↑metabolism
-↑clot formation
DRUG
FACTS
ACTION
INDICATION
CONTRA -INDICATION
ADVERSE EFFECT
INTERACTION
NURSING IMPLICATION
SEDATIVES and
HYPNOTICS
(continuation)
*Types:
-Benzodiazipines Most frequently prescribed. d/t Safety,efficacy
*Classification:
>SEDATIVE-HYPNOTIC
>ANXIOLYTIC- ↓ anxiety
-Non-Barbiturate Non-Benzo
-↓CNS activity
- no REM suppression
-(+) calming effect
-muscle relaxation
*agitation
*depression
*epilepsy
*mod conscious sedation
*same as above under antianxiety
*glaucoma
*pregnancy
*headache
*drowsiness, vertigo
*fall hazard
*hangover effect
*CNS depressants
*kava/valerian=↓CNS
*Grapefruit/GFJuice
-alter absorption
*15-30min before bed
*REM rebound-caution!
*NO Alcohol
*rebound insomnia 3-4wks after d/c
*SAFETY:
-siderails up, bed alarms
ANTI
DEPRESSANTS
-tx mood dsorder
*MANIA- emotion
*DEPRESSION-↓emotion
*BIPOLAR-mania+depress
*AMINES:
-dopamine
-Serotonin
-norepinephrine
•ANTIMANIC
*Lithium-DOC
-serum level: 0.6-o.8mmol/L
•ANTIDPRESSANTs
*Types:
-Newer-Gen >SSRIs >2nd /3rd Gen