E Cadherin Research Paper

Breast cancer is a disease that spread among women all around the world. The disease occurs when breast cells grow uncontrollably, they grow and develop to form a tissue that might spread to different members in the body. Breast cells take long time to transform to a cancer cell, and demonstrate symptoms of the disease. There are many causes that lead to breast cancer, such as genetic reasons, age and style of life. In addition, there is protein called E-cadherin, it is likely to cause cancer if it is not working correctly.
E-cadherin is transmembrane protein, and it requires calcium to function. E-cadherin presents between cells to bind them together. Furthermore, it is required for the cell adhesion and maintains integrity of cells. Therefore, …show more content…
As mentioned, E-cadherin is important to bind the cells, so it needs calcium (6) to function. Thus, the E-cadherins will interconnect themselves (self adhesion) in the extra cellular matrix (8). Inside the cell, the inner side of E-cadherin attach with actin filaments (1). However, there is other intermediary proteins to support E-cadherin to interact with actin filaments are α-catenin (3), β-catenin (4) and vinculin (9). This process maintains and established cell-cell cohesion. This process regulates self-renewal and the …show more content…
The absence of E-cadherin and tumor progression: β-catenin has an important role in E-cadherin function, and it is needful for cell adhesion, also it considers as a binding partner for E-cadherin. β-Catenin supports E-cadherin function by acting as a converter for cytoplasmic proteins. β-Catenin is controlled and regulated by APC gene or AXIN gene. These proteins linked to cancer strongly. So, loss function of APC gene or AXIN gene lead to irregular activity of β-Catenin, grow cells out of control, and form abnormal tissues that might transform to cancer.

Finding an effective medicine for breast cancer is important, because it serious and dangerous disease, and many people suffer from it worldwide. Nowadays, there are many treatments for cancer like chemotherapy. Those who suffer from breast cancer of any other type of this disease, they must abide doctors advices, have their treatments regularly. However, everyone should be careful and try to go to doctors to have an early detection of breast cancer, because it saves lives, and women should starting do it after the age

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