Furosemide Research Paper

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Discussion
Albumin, Furosemide or both as combination should always be considered when treating ill patients who are under a critical condition. Based on our study but also to all the information was reported in thesis, it can be clearly understood the controversial role of those drugs.
We should highlight that the usage of albumin in critical ill patients in clinical practice is helpful, as in cases of hypovolemia, acute nephrosis, burns, shock and others. Nevertheless, based on mentioned studies, can be presented the positive (pros) and negative (cons) sites of the use of albumin in critical ill patients.
Pros
 Patients treated with albumin infusion can show a greater improvement in organ function (respiratory, cardiovascular and central …show more content…
 In elderly hypertensive patients can be seen a significant reduction in blood pressure with a marked decreased in plasma renin activity levels [74]
 Furosemide does not suggest that furosemide can reduce mortality in patients with acute kidney injury [68,69,71], in contrast with patients with acute lung injury without haemodynamic instability, furosemide may be useful in achieving fluid balance to facilitate mechanical ventilation according to the lung-protective ventilation strategy [70].
 Furosemide is used in critical ill patients with CHF to enhance urinary Na+ excretion with the target of reestablishing and maintaining Na+ balance and euvolemia. [79]
 Furosemide use in cirrhotic patients can produce positive results in cirrhotic patients. [82]
Pros
 The furosemide augmentation of urinary Mg2+ and Ca2+ excretion can be added to known promoting excretion of Na+, K+, and Cl− that can lead to a hypokalemic, hypochloremic and metabolic alkalosis. [79]
 The furosemide adverse effects of intravascular volume contraction and RAAS activation at rest and during exercise can be seen in untreated, euvolemic patients without chronic heart failure.
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