The Nazis believed that Jews were a threat to the Aryan race. Just as mice are associated with filth and disease, so too were the Jews. This association can be traced back in history to the Black Death when infected rodents infested one third of the European population with the Black Death, which in turn killed them. The Nazis despised them and aimed to exterminate them just as one would exterminate mice, or pests. Throughout World War II, the Nazis posted propaganda posters of Jews portrayed as rats, the relative of the mouse. Spiegelman uses the analogy of the Jewish mice to bring attention to the Nazi ideology and its flaws. During World War II, the Nazi’s used the Jews as test subjects in live human experiments. Rats and Mice have been used throughout history to test and research different theories regarding a myriad of scientifically and physiological questions. Thus, Spiegelman’s analogy was an effective and powerful representation of Jewish people the Nazi