Hippocampal Neurogenesis

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Neurogenesis is the tightly regulated multistep process that involves proliferation and differentiation of neural stem cells/neural progenitor cells (NSCs/NPCs) and then their survival and integration into functional circuitry (PMID: 15271491, PMID: 18295581, PMID: 17277773, (PMID: 11875571). Main neurogenic region in the brain includes sub-granular zone (SGZ) of dentate gyrus (DG) in the hippocampus and sub-ventricular zone (SVZ) of the lateral ventricle where neurogenesis persists throughout lifespan in mammals (PMID: 18295581, PMID: 11875571). SGZ contains NSCs/NPCs that producing thousands of new granule cells per day (PMID: 11406822, PMID: 15788705). These newborn hippocampal neurons are functionally integrated into the existing neuroanatomical circuitry (PMID: 11875571) and play important modulatory role in the hippocampus-dependent learning and memory processes ((PMID: 11875571, PMID: 24744707). …show more content…
Rate of adult neurogenesis modulated by array of exogenous and endogenous factors (PMID: 8604047, PMID: 9087407, PMID: 9294224, PMID: 11602648). Positive factors that enhances the neurogenesis includes running, exercise (PMID: 10557337), enriched environment (PMID: 24123782,), learning (PMID: 11268214), mood stabilizers (Lithium) (PMID: 15056276, PMID: 10987856, estrogens (PMID: 10407020) and antidepressant drugs (PMID

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