Hypertensive Crisis Research Paper

Identifying Medically Feasible Solutions to a Hypertensive Crisis
Alexander Iacobucci, Brett Johnson, Andrew Hassall, Gregory McDonald
Texas A&M University

Introduction: High blood pressure stems from high systemic resistance and may be the largest cause of hypertensive crises, a severe increase in blood pressure that may lead to a stroke. The goal of this research is to increase cardiovascular output and contractility in order to lower severe pressure to bring a patient back to ‘normal’ levels.

Methods: The model used to obtain information for this study was the closed loop cardiovascular model, developed by Dr. Christopher Quick. The parameters that were modified in this model were chosen due to the effectiveness of the counteractive change. The parameters were adjusted to overcome …show more content…
The modifications indicated present the necessary percent changes in order to nullify the increased systemic resistances effect on systemic arterial pressure, and may lead to the recovery of a patient from a hypertensive crisis. The highlighted values represent the adverse consequences of the changes to the corresponding variables.

Results and Discussion: The four parameters that stood out enough for discussion were Emaxlv, Eminlv, Rp, and VB, which can be viewed in the figure below. Emaxlv presented extremely encouraging results after requiring a 90% decrease in contractility in order to effectively bring systemic arterial pressure back into normal ranges. Interestingly enough, this result would advocate for inducing cardiac arrest in patients experiencing hypertensive crises, a seemingly non-intuitive conclusion. A moderate reduction in blood volume (VB by 12%) also showed similar positive counteractive effects. This would indicate that the bodies feedback mechanism of kidney filtration may be incredibly useful in preventing a hypertensive crises. In essence, the kidney’s inherent functions could be coerced through the use of medication to effectively lower the patient’s

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