Lignocaine or lidocaine is synthetic compound used as a local anaesthetic. It is a short-acting local anaesthetic with marked vasodilator and antiarrhythmic properties. Lidocaine hydrochloride stops the feeling of pain. As local anesthetic, efficacy of lidocaine is characterized by rapid onset of action and intermediate efficacy. On the other hand, epinephrine vasoconstricts arteries, reduce bleeding and also delays the resorption of lidocaine, doubling the duration of anaesthesia. Lidocaine also makes local freezing less painful. Lignocaine is a non depolarizing blocker and absorbed through parenteral administration. In order for foot withdrawal reflex, spinal nerves (sciatic nerve) in the abdominal cavity is stimulated by the local anesthetic…show more content… A brisk reflex occurs. The normal saline then terminates the action potential generated and the reflex. This acts as a control for our observation for the functional of the peripheral nervous system of the frog. As local anaesthetic, its mechanism is by reversible blocking the sodium voltage gated channel. As an electrical signal reaches a threshold voltage level then propagates along its length it opens sodium channels to allow an influx of sodium ions. These sodium channels are proteins that sit across the membrane that forms the surface of the nerve. This protein folds into a cylindrical shape with a central channel that can be opened and closed in response to voltage signals from the nerve cell. The local anaesthetic works by moving to the inside of the cell then binding to the sodium channel and so blocking the influx of sodium ions. This block stops nerve conductance and prevents signals reaching the brain. When there is no action potential, there will be no activation of the receptor, no information transfer and thus no muscle
