1. INTRODUCTION Comment by Roger Bourne: Don’t use colons unless absolutely necessary.
1.1. What is the need of histological validation of Non-Invasive medical imaging?
The histological validation of non-invasive image is significant for many purposes such as the radiotherapy treatment planning (RT)[1, 2] and validate new tracers[3]. Histology is the gold standard to validate many medical exams such as findings of biopsies and non-invasive images [4, 5]. Relying only on the results …show more content…
Thus, the limitations of the first category of registration methods are avoided by using internal instead of boundaries only. Also, the limitations of second registration methods are avoided where local patches around detected landmarks have salient structure information for correspondence matching, so, misregistration from distortion and cutting artifacts of histologic images can be …show more content…
at el, [68] in context of radiotherapy. Each one of these criteria encounters challenges to complete a satisfied image registration in different contexts (sources). However, our focus is the relationship between the histological and non-invasive imaging parts and the main issues that could be more related to the histology process and make the validation more complicated due to the differences in the nature of theses images. Differences between histological and non-invasive images relate to the acquisition process, resolution, and type of the information that result from these two