The exocrine portion of the pancreas is the portion which creates enzymes which are subsequently used in the digestive system (duodenum). Connective tissue septae allow the pancreas to be divided into pancreatic lobules. These lobules are composed largely of the acini exocrine cells, arranged in grape-like clusters, with their purpose being the manufacture and secretion of digestive enzymes, used to further breakdown food into nutrients usable by the body. The pancreatic juice containing these enzymes is secreted by acinar cells and epithelial cells, with secretion regulated …show more content…
As with a pancreatic lobule, the lobule of the liver is roughly hexagonal in shape, with portal triads at the vertices and a central vein in the middle. Connective tissue sheets divide the liver into thousands of these lobules ‘units ‘.
The functional cells of the liver are hepatocytes. Hepatocytes play a number of roles within the body in metabolism and secretion. The polygonal liver hepatocyte possesses a central nucleus, a granular cytoplasm, with clearly outlined margins between fellow bordering hepatocytes. They are a type of cuboidal epithelia. The hepatocytes ultrastructure reflects their vital role in metabolism, with abundant rough and smooth endoplasmic reticulum, and Golgi membranes. Vesicles with very low density (VLD) lipoproteins, along with glycogen granules, are common.
Hepatocytes, after absorbing solutes from the plasma, are responsible for the synthesis and secretion of most plasma proteins, including …show more content…
Hepatocytes on the basal surface possess microvilli which project upon the sinusoids. The proximity of the hepatocytes to these capillaries means that they have ready access to the blood for processing of its constituents. Sinusoids are populated with Kupffer cells. Kupffer cells, which are members of the mononuclear phagocyte system and therefore act in defence of the host immune system, bulge out on the luminal side of the sinusoids.
The space, or cleft, between the fenestrated endothelium sinusoidal lining cells and the surface of hepatocytes is called the Space of Disse. The Space of Disse collects lymph, which is subsequently delivered to lymphatic capillaries. In the space of Disse hepatic stellate cells (perisinusoidal pericytes) are located, which form scar tissue in reaction to liver damage.
Between hepatocytes, fit bile canaliculus, ducts which accumulate the hepatocytes bile manufactured. From here, bile flows first into bile ductules and then into bile ducts, eventually onto the gall bladder via the common bile duct. The apical surface forms the