Pernicious Anemia

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To reiterate a diagnosis of pernicious anemia, this is a disease that lacks intrinsic factor produced by the parietal cells, resulting in a decrease of Cobalamin (Vitamin B12) absorption in the intestine. Pernicious anemia is a subtype of megaloblastic anemia due to a deficiency of vitamin B12. This deficiency results in ineffective hematopoiesis showing a marrow with abnormal erythroblasts. There is two types of autoantibodies associated with parietal cells in PA, type I are the blocking antibodies and type II are the binding antibodies. When a person has these antibodies they will permanently test positive for PA parietal antibodies. The average age of PA diagnosis is 60 years of age and in more predominate in the Scandinavian and Northern
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