Analgesics solubility
Aim: Compare the rate of solubility of analgesics in their dispensing form
Independent variable- dispensing form
Dependant variable- rate of solubility
Controlled-
*water 37 degrees (same as body
*Volume of water
*Same mass of aspirin
*Rate of agitation
Analgesic- aspirin
Dispensing form of aspirin- capsule, enteric coated tablet, soluble active ingredient
50ml water 37 degrees C
Method- Dispense one of the types of analgesics into four separate distilled water filled beakers. One pill in each and have four separate timers with stop watches to record the rate of solubility in dispensing form.
Aspirin Solubility 100mg Aspirin form | Time to dissolve | Soluble | 32.75 seconds | Enteric coated tablet | 2 hours 12 minutes | Capsule | 2 hours 12 min |
Results-
Soluble- After 2 hours and 12 minutes the gelatine casing dissolved and the beads of active ingredients had not. This means that the ingredient might have an enteric coating or needs a different PH to dissolve Time to dissolve | Round coated tablet | Capsule shaped tablet | Fluid filled capsules | Trial 1 | 17:20 min | 8:57 min | 9:32 min | 2 | 17:17 min | 10:15 min | 9:28 min | 3 | 17:21 min | 10:55 min | 6:20 min | 4 | | 10:55 min | 6:41 min | avg | 17.19 min | 9:55 min | 7:40 min |
IBUPROFEN SOLUBILITY 200mg
Paracetamol solubility 500mg Time to dissolve | Tablet | Soluble | Capsule | Trial 1 | | 4:41 min | 8:94 sec | 2 | | 4:53 min | 9:40 sec | 3 | | 4:40 min | 9:50 sec | 4 | | 4:39 min | 10:40 sec | avg | Undissolved at 20 mins
