Phenacetin Synthesis

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Pages: 8
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Synthesis of Phenacetin Compare/Contrast
Purpose:
The purpose of this laboratory report was to evaluate the similarities and differences between Acetaminophen and p-Phenetidine, which were both synthesized from Phenacetin. Through the research that was conducted in the laboratory, one will learn about two different drugs, which was synthesized from Phenacetin. By forming crystals from the Phenacetin, tests for NMR, IR, and melting point was able to be conducted. These tests will allow the reader to understand the similarities and differences between Acetaminophen and p-Phenetidine.

Reactions/Equations:
Reactions:

Equations:

Procedure:
Procedure for Acetaminophen:

• 0.3512g acetaminophen was put into a conical vial, and then 2.4 ml of NaOH was injected into the conical vial via plastic dropper.
• The solution was mixed with a glass rod. All of the particles were dissolved in the process. The solution was left at room temperature for 10 minutes.
• 0.4ml iodoethane was added to the mixture, and then an air condenser was used. The contraption was submerged in water and heated at 70* C for 30 minutes.
• 5ml of water and ice were put into a 100ml beaker. The vial was then rinsed with 0.5ml ethanol. …show more content…
The only step that could have greatly swayed the results was the melting point step. During the first trial, only a minute amount of product was melted during the test. But, in the second test, a greater amount of product was used. There was question raised that the amount of product could have altered the melting point, as it differed greatly in the two experiments. Through research, it was believed that the simple mistake did not change the results of the melting point, or at least not much. Weighing out the product to put into the tube for the melting point would have been extremely difficult and much of the product would have been
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