The role of probability-based sampling method is to minimize bias by assigning a probability value to each individual in the sample. To minimize bias in my study a multiple frames should be used. For example, if I wanted to study vitamin D status in Chicago, different neighborhoods would provide different outcomes. A neighborhood that is predominately African-American or elderly is in all probability likely to have lower circulating vitamin D levels (CDC, 2011). Sampling must be sure to prevent unplanned selectiveness. How would you interpret results from non-probability samples? Describe some of the threats to validity and reliability in data measurement. It would be difficult to determine results from a non-probability sample. Conclusions cannot be drawn about the generalizability of the sample results reflective of the target population because the sample is not representative of the population. A direct threat to external validity would involve an inappropriate sampling frame, such as only sampling persons between the ages of 25-55 when the elderly are likely to be low in vitamin D or isolated and more susceptible to