(OI) is a hereditary connective tissue disorder due to a
3 qualitative or quantitative defect of type I collagen. OI is a rare disease, occurring in one
4 case per 15,000 to 20,000 births and affecting one in every 200,000 individuals,
5 however there are no citations in the literature about the predominance of race or gender
6 [1].
7 The main features of OI are ligamentous laxity, osteopenia, short stature, fractures
8 caused by mild trauma, progressive skeletal deformities, and additional clinical…
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