The id reaction, also known as autoeczematisation or autosensitisation dermatitis, refers to the sudden development of dermatitis at a distant site from a local inflammatory reaction1. A variety of stimuli have been reported to cause id reactions, including allergic contact dermatitis, the prevalence of which is not known. We report a 27-year-old male patient with generalized, pruritic and eczematous eruption following localized shoe dermatitis. Keywords: Id reaction; Autoeczematisation; Shoe dermatitis.
Introduction:
Shoe dermatitis is a form of contact dermatitis caused by the contact of the foot with parts of the shoe containing potential allergic materials. Shoe dermatitis may present a diagnostic and therapeutic challenge …show more content…
ACD is a type IV, delayed-type reaction caused by skin contact with allergens that activate antigen-specific T-helper 1 (TH1) in a sensitized individual4.The typical picture of foot dermatitis is dermatitis over the dorsal aspects of the foot which frequently spreads to the joints of the toes3. Patch testing is the gold standard in the diagnosis of ACD.
Id reaction, or autoeczematisation, is a generalized acute cutaneous reaction to a variety of stimuli, including infectious and inflammatory skin conditions56.A basic requirement for the development of allergic contact dermatitis is the exposure of the skin to contact allergens that diffuse through the layers of the stratum corneum upon contact with the environment. Antigenicity requires allergens of at least 5000 daltons in molecular weight, and may involve the conjugation of small molecular haptens, such as nickel, with autologous proteins present in the skin7.
The pathogenesis of the id reaction is not understood, but the following factors are suspected to play a role in the …show more content…
Dermatophytid reactions are reported to occur in 4%-5% of patients with dermatophyte infections. Id reactions have been reported in up to 37% of patients with stasis dermatitis6.The classic clinical presentation is an acute, intensely pruritic, symmetric, maculopapular or papulovesicular eruption that typically involves the extremities. The eruption usually appears within days to weeks of the primary inflammatory condition. Systemic symptoms may present and include fever, anorexia, lymphadenopathy, splenomegaly, arthralgias, and hematologic abnormalities 7,1.Histopathological examination of the typical papulovesicular lesion reveals a superficial perivascular lymphohistiocytic infiltrate with a spongiotic epidermis, often with vesiculation. Small numbers of eosinophil may be present in the dermal infiltrate. By definition, infectious agents should not be found in the