For 40 years of his medical career, Sidney Farber was dedicated to his life of being a well-known pediatric pathologist who shaped innovations in his field. He is also known for his innovations in modern chemotherapy. Dr. Farber realized that folic acid accelerated the increase in leukocyte production and strengthened the advancement of leukemia. He considered his theory that opposing agents of folic acid would suppress the activity or restrain the reproduction of cancer cells. In 1948, Dr. Farber’s innovative research was released and it showed that many opposing agents of folic acid, for example, aminopterin, created brief decreases in symptoms of kids having acute undifferentiated leukemia. The findings induced the creation and advancement of the use of more chemotherapy agents whether it was alone or in association for treatment of adult and…show more content… Farber later assumed that opposing agents of folic acid may operate in delaying or stopping the reproduction of leukemia causing cells. In November of 1947, Dr. Farber used this hypothesis in his trials when he gave a sequence of opposing agents of folic acid to a total of 16 kids suffering from leukemia and accomplished brief episodes of cures of symptoms or reduction of symptoms for a total of 10 children. In 1948, Dr. Farber documented his findings and shared them with the public within The New England Journal of Medicine. His experiment ended up to not be the correct cure because it was later found that you needed to have different agents to kill different things but while this research was going on, many kids died and were in pain from the toxic and harsh treatment of combination therapy. Using the same agent over and over to kill resistance would never work because the cells would just keep on learning to resist the agent. Giving the agents one at a time would never work because it wouldn’t tackle all of the leukemia symptoms. The treatment needs to be all of the agents at once to target different
