During 200 CE and 600 CE the Hans and the Romans suffered from the outbreak of epidemic diseases. Epidemic disease affected the Hans and Romans in many ways including reduced population, contracting economy, social unrest, and lower moral. Epidemic diseases spread through the silk roads causing massive population decline, disease reduced the population of China and Rome by a quarter to a third from their high points in classical times. Epidemic diseases also contracted the Chinese and Roman economy, both went from a larger economy incorporating various regions to a regional self sufficient