Garg & Karjodkar (2012) presented two case reports where patients displayed lesions that appeared clinically harmless but turned out to be premalignant. Case 1 reported a 53-year-old male patient whose chief complaint consisted of pain on the floor of the mouth that lasted 2 months, but the lesion had persisted for 6 months prior to becoming symptomatic. The patient confirmed he had a 25-year history of tobacco use, more specifically betel quid. Upon oral examination of the patient, the doctor discovered a red lesion with irregular borders that has not responded to prior prescriptions of medications, such as antibiotics, anti-inflammatory drugs, and ointments (Garg & Karjodkar, 2012; Figure