He was the second son of Dr. Joseph Cleburne, a middle-class physician of Anglo-Irish ancestry. Patrick's mother died when he was 18 months old, and he was an orphan at 15. He followed his father into the study of medicine, but failed his entrance exam to Trinity College of Medicine in 1846. In response to this failure, he enlisted in the 41st Regiment of Foot of the British Army, subsequently rising to the rank of corporal.Three years later, Cleburne bought his discharge and emigrated to the United States with two brothers and a sister. After spending a short time in Ohio, he settled in Helena, Arkansas, where he was employed as a pharmacist and was readily accepted into the town's social order. During this time, Cleburne became close friends with Thomas C. Hindman, who would later parallel his course as a Confederate Major General. The two of them formed a business partnership with William Weatherly to buy a newspaper, the Democratic Star, in December 1855. One year later, Cleburne and Hindman were both wounded by gunshots during a street fight in Helena with members of the Know-Nothing Party following a debate. During this fight Cleburne was shot in the back, causing him to turned around and shot one of his attackers, killing him. The attackers hid until Cleburne collapsed on the street and then left. After the two recovered, they appeared before a grand jury to respond to all charges brought against them. They were