Origin of Discovery The origin of this disease is very interesting. The origin of Alzheimer's disease dates back …show more content…
People may experience cognitive problems, such as mental decline, difficulty thinking and understanding, and the inability to recognize common objects. Behavioral symptoms include aggression, difficulty with self care, and wandering around and getting lost very easily. Mood symptoms include anger, apathy, general discontent, loneliness, and sometimes getting mood swings. Psychological symptoms include hallucination, paranoia, and severe cases of depression. Your whole body may be restless or you may have a loss of appetite whenever you are diagnosed with …show more content…
This is called a neurodegenerative disease -- a progressive brain cell death that happens over a course of time. Your overall brain size will decrease with Alzheimer’s -- tissue has progressively fewer nerve cells and connections. While they cannot be seen or tested in the living brain affected by Alzheimer's disease, a postmortem/autopsy will always show tiny inclusions in the nerve tissue, called plaques and tangles. Plaques are found between the dying cells in the brain - from the build-up of a protein called beta-amyloid (you may hear the term "amyloid plaques"). The tangles are within the brain neurons - from a disintegration of another protein, called tau. This disease can be categorized as a genetic mutation. Early-Onset Alzheimer’s is made by chromosomes 21, 14, and 1 whenever any one or all of them are genetically mutated. Late-Onset Alzheimer’s is caused by apolipoprotein E (APOE) gene on chromosome 19 that increases anyone 60+’s risk for Alzheimer’s.
How the Disorder is Inherited Alzheimer's disease is not sex linked, but it can be passed on from generation to generation (and potentially skip generations). It is located on chromosomes 21, 14, and 1. Alzheimer’s is dominant. No recessive genes have been linked to this