The majority of chemotherapy supports the idea that the most rapidly dividing cells are going to be the most vulnerable to the drug. An example of this is methotrexate. Methotrexate is given in very high doses which can be lethal if not monitored properly by a physician. It is an anti-folate. Its purpose is to have competition with folate in the pathway that synthesizes thymine from uracil. Thymine is one of the four nucleotides required for the synthesis of DNA. The cancer cells are the most rapid dividing cells in the body, so they require the highest need for the synthesis of DNA. Methotrexate is supposed to kill off more cancerous than healthy cells, but this is not always the case. Dihydrofolate reductase is a key enzyme that helps to activate folate for thymine. The methotrexate drug will actually attach itself to the dihydrofolate reductase and block the pathway at this step. The blockage triggers a misincorporation of bases into the tumor's DNA, which will possibly cause the cell to die. The problem that has been discovered is that drugs like methotrexate can often be ineffective to a tumor. The tumor can be immune to this specific type of treatment, causing further trauma to the body. With the possibility of undergoing long periods of time in which drugs are being pumped into your body, and no healing occurs, this can be a reason why someone may choose to stay away from …show more content…
Some of these side effects include nausea, anemia, fatigue, infections within the body, diarrhea and vomiting, hair loss, and destruction of the immune system, causing a person to be highly susceptible to any illnesses that they may come into contact with. Research by E. Hall et al. (2014)supports the claim that chemotherapy has many disadvantages. The study compared two types of chemotherapy on 830 patients with breast cancer. The 830 patients were studied for five years. The study concluded that the expected negative effects of the chemotherapy caused only disruption and stress during treatment and there was no improvements in the cancer outcome after five years. The patients were only put through five years of stress to find out that their cancer was not eradicated completely. Clearly, chemotherapy can deter the patient from using the method just based on the rate of success. Pedersen, Koktved, & Nielsen (2013) conducted a study which determined the impact on everyday life from undergoing chemotherapy treatment. The study found that patients not only struggled with physical symptoms but also found it nearly impossible to try to take care of themselves and gain enough knowledge to maintain a normal every day life. It seems that chemotherapy has many disadvantages that can cause a patient to choose a different method of