Coagulation Disorders Essay

Submitted By Hazin-Begum
Words: 574
Pages: 3
Open Document
APPROACH TO
COAGULATION DISORDERS
Dr.K.Pavithran, MD, DM
Assistant Professor,Dept of Hematology
Medical College Hospital
Trivandrum-695011, India

Clinical approach
1.
2.
3.
4.

Is the bleeding significant ?
Local Vs Systemic ?
Platelet Vs Coagulation disorder ?
Inherited Vs Acquired ?

Laboratory Approach
1.
2.
3.
4.
5.

Demonstration of the defect
Identification of the defect(s)
Assessment of severity
Consequential studies eg. carrier detection
Monitoring of treatment

Screening Tests
1. Platelet count & morphology
2. Bleeding Time
3. Clotting Time
4. Prothrombin Time
5. Activated Partial Thromboplastin Time
6. Thrombin Time

Collection of blood sample
1. Minimum circulatory stasis
2. Clean venous puncture
3. Proper anticoagulant
4. Proportion of blood to anticoagulant
5. Separation of plasma and storage
6. Effect of stress, pregnancy, drugs
7. Effect of PCV on the proportion of plasma to anticoagulant

Prolonged PT/APTT
•
•
•
•

Coagulation factor deficiency/inhibitor
Test plus control plasma - 1:1
Repeat PT/APTT
> 50% correction
– Yes - Factor deficiency
– No - inhibitor timed incubation abnormally increasing specific inhibitor

no change
Lupus Anticoagulant

HMWK

VII

XII
PK
XI
APTT
IX

PT

VIII

X

PT - 
APTT, TT, PLC - N

* Factor VII deficiency
* Anticoagulant therapy

V
II
I

TT

HMWK

VII

XII
PK
XI
APTT
IX

PT

VIII

X

APTT - 
PT, TT, PLC - N

* Factor deficiency
* vWD
* Inhibitors
* Heparin therapy

V
II
I

TT

Mixing tests with APTT
APTT of test plasma +
Aged plasma
Adsorbed plasma
Diagnosis
No correction

Corrected

VIII

Corrected

No correction

IX

Corrected

Corrected

XI,XII

Prolonged APTT, BT von Willebrand’s disease
Ristocetin Induced Platelet Agglutination
VIII:C
vWF:Ag vWF multimeric analysis
Type 1 - Partial deficiency of vWF
2A - Absence of large and interm. multimers
2B - Absence of large multimers
2M- multimers normal, pl. function 
2N -  affinity for FVIII
3 - severe deficiency of vWF

HMWK

VII

XII
PK
XI
APTT
IX

PT

VIII

X

PT, APTT - 
TT, PLC - N

*
*
*
*

V
II
I TT

Common Pathway Factor deficiency
Vitamin K deficiency
Oral anticoagulant therapy
Liver disease

Mixing tests with PT
PT of test plasma +
Aged plasma

adsorbed plasma

Diagnosis

Corrected

Not corrected

X

Not corrected

Corrected

V

Not corrected

Partial

II

HMWK

VII

XII
PK
XI
APTT
IX

PT

VIII

X

PT, APTT, TT - 
PLC - N

* Hypo / dysfibrinogenemia
* Heparin
* Liver disease
* Systemic hyperfibrinolysis

V
II
I

TT

HMWK

VII

XII
PK
XI
APTT
IX

PT

VIII

X
Show More

Related Documents: Coagulation Disorders Essay

Disseminated Coagulopathy Research Paper

Abstract Disseminated intravascular coagulation, also referred to as “consumption coagulopathy” or “DIC,” is an abnormality in the body’s normal blood clotting process. During this condition, excessive clotting occurs throughout the small blood vessels of the body. This widespread clotting depletes existing clotting factors and platelets leaving the body unable to form a clot at the site of a real tissue injury. As a result, extensive bleeding occurs. Bleeding from multiple sites is the most common…

Words 727 - Pages 3

Analysis Of Haemostatic Defects

Analysis of haemostatic defects Patient 1: Factor V Leiden (fV Leiden) The patient does not have any abnormal blood results that are apparent from the blood tests conducted. The fV Leiden mutation is a common missense mutation in the factor V coagulation factor which causes an increase in the tendency for blood to clot. Factor V’s activity is usually regulated by activated protein C (aP) and the mutation causes fV to become resistant to the anticoagulant effect of the aPC pathway by preventing efficient…

Words 1973 - Pages 8

Deep Vein Thrombosis Essay

000 people are hospitalized yearly with DVT’s in the U.S. (cdc.gov). Alterations in hemostasis and blood coagulation are the process by which blood clots form. Hemostasis refers to stoppage of blood flow. It is designed to maintain the integrity of the vascular system. The process of hemostasis is divided into five phases: which are vessel spasm, formation of the platelet plug, blood coagulation, clot retraction, and clot dissolution (Porth, 2004). Injury to the endothelial initiates vessel spasm…

Words 3937 - Pages 16

Essay on Hemophilia: Coagulation and Von Willebrand Factor

Hemophilia is rare hereditary coagulation disorder due to deficiency or reduced activity of factor VIII or factor VIIII. Hemophilia word came from Greek language where haimo means blood and philia is affection. Hemophilia sometimes called royal disease as it affected the large number of royal males during 19th and 20th centuries. Queen Victoria believed to be the carrier of Hemophilia B which she passed to her off springs. Hemophilia is x linked recessive disorder, female are carrier and males are…

Words 940 - Pages 4

How And Where Are Platelets Produced In The Body?

adhesive and cohesive functions that leads to the formation of a hemostatic plug. Second, they can activate coagulation mechanisms through the exposure of an adequate phospholipidic surface, acting as a catalytic site for the development of coagulation and the consolidation of the hemostatic plug. 3. Define thrombocytopenia and list the more common causes of this condition. Blood disorder characterized by an abnormally low number of circulating platelets (thrombocytes) in the bloodstream Decreased…

Words 325 - Pages 2

Factor 23 Factor 8

Factor 8 by Key’Ana Banks Factor 8 also recognized by factor VIII or it’s official name of coagulation factor VIII, procoagulant component is a blood clotting protein. It is also known as the anti-hemophilic factor (AHF). It’s official symbol is F8s humans factor 8 is encoded by the F8 gene. If this gene has a defect it may result in hemopphilia A which is a recessive X linked coagulation disorder. en.wikipedia.org/wiki/Factor_VIII Factor 8 is located on the x chromosome. This intreguing gene’s…

Words 704 - Pages 3

Hemophilia Research Paper

Introduction Hemophilia is a rare genetic blood clotting disorder that primarily affects males. People living with hemophilia do not have enough of, or are missing, one of the blood clotting proteins naturally found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia), clotting factor VIII is not present in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease), clotting factor…

Words 2376 - Pages 10

Essay on Hemophilia: Haemophilia B and Specific Exercises

known as Hemophilia. Like the majority of diseases, Hemophilia has causes, symptoms, and different types of information. First, according to Microsoft Encarta 2008, Hemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. Hemophilia does not allow a wound to scar and so the bleeding continues, possibly causing death in extreme cases. In addition, there is one main cause…

Words 929 - Pages 4

Essay on Haemophilia: Blood and F 9 Haemophilia B .

Genetic Disorder Introduction: Genetic Disease or disorder is a change that occurs in each individual’s DNA that makes up the gene. A disorder results when a gene is mutated and the protein product can no longer perform its normal function. They can be inherited because they are a change in the germ cells which passes the genetic information from parents to its offspring. Also it can have changes in the DNA in somatic cells or in other body cells; mostly it doesn’t has to be the in…

Words 3305 - Pages 14

BS0504 Module Guide 2013 14 Essay

cells in blood and bone marrow smears. Cell surface markers Haemostasis & fibronolysis: The interralationship between the haemostatic and fibrinolytic mechanisms. Disorders of haemostasis: Hereditary and acquired disorders including thrombocytopaenias and thrombocytopathias. Coagulation defects, performance and interpretation of coagulation tests. Anticoagulant therapy and its monitoring. The anaemias: Classification of the anaemias. Abnormalities in red cell morphology in anaemia. Haemoglobinopathies…

Words 960 - Pages 4