Factor 8 also recognized by factor VIII or it’s official name of coagulation factor VIII, procoagulant component is a blood clotting protein. It is also known as the anti-hemophilic factor (AHF). It’s official symbol is F8s humans factor 8 is encoded by the F8 gene. If this gene has a defect it may result in hemopphilia A which is a recessive X linked coagulation disorder. en.wikipedia.org/wiki/Factor_VIII Factor 8 is located on the x chromosome. This intreguing gene’s factor presents an interestingly uncommon structure with another gene embedded in one of it’s introns. FVIII is known as a glycoprotein pro-cofactor ( a surface membrane glycoprotein made of a heterodimer, an alpha chain and a beta chain, which are all linked by disulfide bonds). Even though the main site of liberation in humans is ambivalent it is in sync and freed into the human bloodstream by the vascular, glomerular, and tubular endothelium, and the sinusoidal cells located in the liver. Lucky for us hemophilia A has been corrected by liver transplantation. Replacing hepatocytes unfortunately is ineffective, yet somehow the endothelial liver cells were effective.
Factor 8 …show more content…
there is a 50 percent chance your son will have it. There is also a 50 percent chance that your daughters will be carriers of the gene. The X gene contains many genes thatre a different than those that are present on the Y chromosome. This shows that males only have one copy of most of the genes on the X chromosome where women have 2. This means that a man can have the disease if they inherit an affected X chromosome tnat has a mutation. Girls can also have hemophilia but this is much rarer. Hemophilia can result in bleeding inside the joints which may start an unhealthy disease or unnatural pains. It can also start bleeding in the brain. Which may paralyze you.