While domesticated animals like horse and cattle where beneficial to the New World, the Columbian exchange also brought disease and epidemics. Disease associated with the Old World’s dense populations and animals such as chickens, rats, and mosquitoes affected the New World. Among these were the following: smallpox, measles, chickenpox, influenza, malaria, and yellow fever. These pathogens killed off at least 90% of the Native American Population. Smallpox, one of worst pathogens introduced to the New World, caused an epidemic in 1518 that