They went to the river and drank the brackish water. They drank so much of that bad water that some of the settlers got a disease called saltwater poisoning. This led to a lot of the settlers dying. On top of the that, some of the settlers grew suspicious that there were Spanish spies in the midst of them. They shot able-bodied men, just because of a suspicion. This lead to much more deadly. They had fewer people to hold down the fort and even less to plow the fields. The Powhatan took siege over the settlement. Even though the settlers won only 50 of them