Lecture 6: Antioxidants And Nutraceutical Or NHP?

Submitted By sgore1995
Words: 653
Pages: 3
Open Document
Lecture 6: Antioxidants and chemoprevention

Antioxidants
Are they Nutraceutical or NHP?
There was confusion, first it was NHPD because faster and allowed medical claims
Health Canada says if it is sold in capsule or tablet it is NHP but sold as drink or additive in food it is food
Many natural products can be formulated as either NHP or Nutraceutical
Ex. Cranberry extract in capsules is NHP but cranberry juice is Nutraceutical.
ROS
ROS- reactive oxygen species, generated many processes including in oxidation of food in mictochondria.
ROS like superoxide, hydroxyl radical and singlet oxygen have been degenerative in ageing, cancer cardiovascular disease and diabetes.
Antioxidant hypothesis
Theory of ageing: vit c and e not effective in clnical trials but work shows dietary fruits and veggies are high in +ve long term effects.
Cardiovascular disease, cancer, stroke
Dietary antioxidants include vit c and e, carotenoids, but recent studies show still beans flavonoids and anthocyanin’s highly significant
Flavonoid intake from fruits and vegs is 50-800 mg per day, red wine and tea contain 200 mg/serving
Antioxidant redox assay
Hydrogen atom transfer assay (HA): ORAC radical scavenging
Single electron transfer: FRAP
Combined methods : DPPH and total phenolics

ORAC
Oxygen radical absorbance capacity: flurosence destroys by ROO.
Antioxidant removes ROO
Uses fluorescent probe, green dye and destroy peroxide with peroxide dye.
FRAP
Ferric reduction antioxidant power assay- single electron by ant oxidant, take radical give up h from oh and convert to RH radical stabalized.
Antioxidant bioassays
1. COX (cyclooxygynase) enzyme inhibitor
2. MDA (TBARS) – lipid peroxidation
Measure of lipid peroxides
3. 8OHdG DNA damage
Mesure nucleic acid oxidation (damage)
4. Savaenging of superoxide radicals

-green tea catechins are potent antioxidant but lose some of their activity when fermented to black tea
-ability scavenge super oxide radicals. Need certain amount of epicatechin to get rid of 50% superoxide radicals. Need least amount of substrance!!
Anti oxidants and French paradox
Red wine cause lower in cardiovascular and cancers
Red wines contain potent antioxidant-stillbean called RESVERETROL, also found in blueberries.
ROS suspected roles in CVD, cancer diabetes and many other degenerative disease.
Resveratrol from red wine inhibits inflammatory enzyme COX(cyclooxygenase), hydroperoxidase activity and formation of cancer lesions in mouse model
Mouse Study
Resveratrol added mouse diet, mice has reduced # of tumors
Resveratrol inhibits tumorigenesis
Can reduce high glucose levels and insulin, improving insulin sensitivity.
Anti-diabetic pharmaceuticals.
Gains
Corn has highest antioxidant potential any grain due to higher phenolic content.
Purple corn
Purple corn ceremonial variety used indigenous
Show More

Related Documents: Lecture 6: Antioxidants And Nutraceutical Or NHP?

Module 6 Audio Lecture Essay

auditor’s opinion 5. if an overall opinion is expressed, it must include: the scope and time period, consideration of related audit projects, the risk and control framework used as a basis for the opinion; and the reasons for an unfavourable opinion 6. reports may include recommendations and acknowledge satisfactory performance and corrective action 7. the auditee’s views about conclusions and recommendations may be included in the report 8. the CAE or a nominee should review the final audit report…

Words 671 - Pages 3

Lecture 6 Culture Su14 Essay

Culture and Authentic Leadership Cultural Processes • All cultures have accepted ideas about appropriate behavior: Norms – Grease social machinery – Don’t have to think about them (culture shock)  Personal space – Highly adaptive and functional What is Organizational Culture? Creating and Maintaining Organizational Culture Founder Founder values valuesand and preferences preferences Industry Industry demands demands AttractionAttractionselection-attrition selection-attrition Early Earlyvalues…

Words 1226 - Pages 5

Section 6 Lecture Audit Planning And AP Essay

Section 6 – Audit Planning and Analytical Procedures image source: Figure 13-9 from Arens, Elder, and Beasley, Auditing and Assurance Services: An Integrated Approach, 15th ed Page 1 Section 6 – Audit Planning and Analytical Procedures Planning the audit  AICPA Principles of Performance: “The auditor must adequately plan the work and must properly supervise any assistants”  Why plan? 1. 2. 3. Page 2 Section 6 – Audit Planning and Analytical Procedures Early Audit Planning Aids in Risk…

Words 685 - Pages 3

Essay Unit 1 Lecture 6 PES Shielding Effect 2

Spectroscopy (PES) & Shielding Effect Unit 1 Lecture 6 Shell Model and the PT Shell (n) # of Row of Periodic electron Table & # of s it can elements in it hold n=1 2 1st row has 2 elements n=2 8 2nd row has 8 elements n=3** 8 3rd row has 8 elements **Learn later, the 3rd energy level can actually hold 18 electrons o Can anyone remember why? Electrons • Inner core electrons o are in the inner shells • Valence electrons • are in the outer most shell Spectroscopy • In these experiments…

Words 1176 - Pages 5

Cf2 Study Guide 2013 Essay

| | |Day 2 |Course Introduction/Facility Tour/Professionalism/Foundations I Curriculum Review/Stocks/Leading Sauces |Lecture: 3 hr 15 min. | |Lecture 1 |Read pgs. 227-240 LCBCF | | |Tuesday 5-22-12 |…

Words 573 - Pages 3

Module: International Economics Essay

Learning Outcomes | P.2-3 | 3. Contact and Study Hours | p.3 | 4. Learning and Teaching Methods | p.3 | 5. Key Texts | p.3 | 6. Assessment Overview | p.4-5 | 7. Academic Misconduct | p.4 | 8. Late Submission | p.4 | 9. Attendance and Punctuality | p.5 | 10. In Case of Illness | p.5 | 11. Weekly Schedule | p.5-6 | Welcome to FC006, International economics. This is a core module that provides an introduction to the topics involved in the study of Business…

Words 1389 - Pages 6

Essay on Observational Atomic Structure Notes

element are identical. 3. Atoms of different elements can physically mix or chemically combine. 4. Chemical reactions occur when atoms are separated, joined, or rearranged. ” [ ] 5. An atoms concerned unit (that is smaller) is also known as? A quark. [ ] 6. A quarks concerned unit (that is smaller) is also known as? Cosmological String; Superstring Theory, vibrates in a restricted domain because of theoretical dimensions (one reason for the request of the LHC(Large Hadron Collider); to prove theoretical…

Words 756 - Pages 4

Essay on MN2205 Course Outline

and how to set them in the context of key developments in which contemporary business operates. The course consists of 16x one-hour lectures and 9 one-hour workshops. The lectures are used to illustrate the key points under each topic as well as real business examples. Workshops will be used for case studies and applications of the material covered in the lectures. The aim of the module is to introduce the student to the way in which a firm can achieve sustainable competitive advantage through strategy…

Words 1330 - Pages 6

Essay on Part 1 60 Pointsout Of 10010

(power point, lecture notes, and Spielvogel, p. 807) 3) The Great Depression (power point, lecture notes, and Spielvogel, p. 815- 6) 4) Bolshevik Revolution (power point, lecture notes, and Spielvogel, p. 799- 800) 5) Weimar Republic (power point, lecture notes, and Spielvogel, p. 826) 6) Hitler’s ideology (power point, lecture notes, and Spielvogel, p. 826-829) 7) Policy of Appeasement (power point, lecture notes, and Spielvogel, p. 853- 855) 8) Operation Barbarossa (power point, lecture notes, and…

Words 313 - Pages 2

Essay on Exam Sample

Examination Information for ORDINARY, DEFERRED AND SUPPLEMENTARY EXAMINATIONS Time Allowed: THREE (3) hours + 15 minutes reading time (you are permitted to write during reading time) Instructions: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. There are SIX (6) questions to be marked out of a total 100 marks. Some questions have more than one part. Answer ALL questions. You may answer the questions in any order but PLEASE clearly identify the question you are attempting at…

Words 837 - Pages 4