A typical patient with ESRD is expected to fulfill dietary restrictions, an elaborate medication regimen, fluid restriction, smoking cessation, and doctor appointments. Furthermore, patients will be given an array of choices for treatment options such as hemodialysis or peritoneal dialysis (Martino, 2011). With many restrictions and adjustments, patients may feel lifeless, which can lead to noncompliance and poor clinical outcomes (Martino, 2011). Motivational interviewing (MI) is a beneficial approach for nurses to help strengthen patient’s interest and adherence in their treatment (Rollnick, Miller, & Butler, 2008). The purpose of this paper is to highlight the key principles of MI and the process and skills required to carry out