Written Assignment Unit Five Introduction The most important thing for cells is to be able to synthesize proteins based on DNA. This involves the central dogma of life. DNA makes copies of itself through replication and it is transcribed into mRNA and then translated into protein.
Protein: Chaperone Function Chaperones are proteins that help in protein transportation to the correct subcellular compartment. They help in maintaining protein homeostasis, ensuring the proteins proper function, and prevents protein misfolding and aggregation (Neural Academy, 2019).
Structure The HSP-60 chaperones is made up of coloured rings of GroEL protein and a cap on one side that is composed of GroES (PDB101, n.d.). …show more content…
HSF 1 regulates the expression of heat shock factor proteins (HSPs) which includes HSP70 and HSP90 (Prince et al., 2020). Hence, in stressful conditions involving heat, the HSP1 binds to HSEs, a specific DNA sequence that is called Heat Shock Elements which is located around the HSP gene promoter region (Prince et al., 2020). This process speeds up transcription and increases the production of chaperones. Meanwhile, histone acetyltransferase p300 HAT is an example of an epigenetic regulator that acetylates histones, relaxes chromatin, and helps transcription factors to be more accessible to DNA (Wang, Tang, Cole, & Marmorstein, 2008b). Both the transcript or factor and the epigenetic regulator HSP1 and p300 HAT helps to regulate the expression of chaperone gene in terms of stressful conditions and ensures that proteins fold