Osteoarthritis Research Paper

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Osteoarthritis (OA) is a common disease, of the articular joint including joint degeneration, inflammation, and upregulation in pro-inflammatory cytokines in synovial fluid (synovitis) [1]. Collagen type 2 and glycosaminoglycans (GAG) are the two major essential components of the extracellular matrix of the articular cartilage that lost after articular cartilage injury [30]. OA symptoms including muscles weakness, synovial inflammation, degeneration of articular cartilage and bone remodeling [27]. The pro-inflammatory cytokines in the joint microenvironment lead to cartilage degeneration through altering the proteoglycans and collagen fibers specially collagen type 2 of the cartilage ECM [16]. Many pro-inflammatory components like interleukin-1β (IL-1β), Tumor necrosis factor (TNF), and Interleukin 6 (IL-6) that produced by cells in the joint, induce the matrix metalloproteinase enzymes (MMPs), which degrade the cartilage extracellular matrix (ECM) and inhibit cartilage formation [2]. IL-1β is the trigger that induces OA through synthesis the chemokines, cytokines and proteolytic enzymes that degrade the cartilage ECM and because the cartilage has a poor repair capability, OA leads to terminating joint movement and requirement of joint arthroplasty [17]. MMPs enzymes activity disturb the cartilage homeostasis, stability and function, those enzymes including collagenases ( …show more content…
Recently, many researchers hypothesized that using the pulsed electromagnetic field stimulation (PEMF) without any biological incitements, can improve the production of the cartilage ECM and some anabolic factors like TGF- β 1 that in the final results may control the OA development and help in cartilage regeneration

Osteoarthritis Research Paper

Osteoarthritis is a chronic condition that diminishes the structure and function of one or more joints by the progressive loss of cartilage. The knees, hips, lower back, neck, joints within the fingers, and the base of the thumb is where Osteoarthritis (OA) occurs the most. With this condition there are different stages; Early Stage- The first stage is the phase is where the cartilage that coats the ends of our bones begin to thin out. At this stage treatment is simple to help lower the symptoms…

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Osteoarthritis Research Paper

OSTEOARTHRITIS Osteoarthritis, also known as degenerative arthritis, degenerative joint disease or osteoarthrosis, is a group of age-related abnormalities involving degradation of joints, including articular cartilage as well as subchondral bone. Symptoms usually include joint pain, tenderness, stiffness and sometimes joint effusion. Osteoarthritis is caused by physical stress on the joint, and is not caused by inflammation, although inflammation can result from physical damage. Symptoms Symptoms…

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Osteoarthritis Research Paper

Osteoarthritis is a form of arthritis common among millions of people across the world. The illness results from wearing down of protective cartilage at the end of the bones over time. The disorder affects hands, hips, knees, and spine. Conditions of osteoarthritis gradually worsen. However, when the patient stays active, undertakes regular exercises and maintains a healthy weight, the progress of the disease slows down. These would help reduce pain and improve functioning of joints. The main symptoms…

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Osteoarthritis Research Paper

Osteoarthritis Did you ever think how many people are suffering with Osteoarthritis (OA) ? According to the Center for Disease Control and Prevention Nearly 1 in 2 people may develop symptomatic knee Osteoarthritis by age 85 years. The Healthy people 2020 goal is to Prevent illness and disability related to arthritis and other rheumatic conditions, osteoporosis, and chronic back conditions and have major effects on quality of life, the ability to work, and basic activities of daily living. The purpose…

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Osteoarthritis Research Paper

Osteoarthritis Description: Osteoarthritis is the most common form of arthritis. Normally the cartilage in the joint is a firm, slippery tissue. The purpose of the cartilage in the joint is to allow the joint to move frictionless1. When the cartilage is unable to allow the joint to move frictionless, this is when the joint is considered to have osteoarthritis. The reason that the joint isn’t able to move frictionless is because the slick part of the cartilage becomes rough or the cartilage might…

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Osteoarthritis Research Paper

causes hip pain and what you and your healthcare team can do to manage the problem. Some of the causes of Hip pain are as follows: Osteoarthritis Osteoarthritis is one of the most common causes of hip pain in adults. It’s often linked to earlier fractures, trauma or childhood hip problems, although it can often occur randomly. We don’t yet fully understand why osteoarthritis develops without any pre-existing problems, but it can cause a great deal of pain, restricted movement and a limp. In extreme situations…

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Osteoarthritis Research Paper

Osteoarthritis There are more than a hundred kinds of arthritis, osteoarthritis being the most common one. It is also known as the degenerative joint disease. It is caused by breakdown, inflammation & loss of cartilage in joints. Risk factors linked to osteoarthritis are obesity, genetics & an earlier trauma to the joint. Osteoarthritis is more in women as compared to men, especially post the age of 45 years. Younger people can also develop osteoarthritis usually resulting from some joint injury…

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Osteoarthritis Research Paper

Previously, osteoarthritis was labelled as a progressive and degenerative wear and tear process of articular hyaline cartilage in the synovial joint, as an inevitable consequence of aging1,2. It was characterised by joint pain, stiffness and limited range of movement1. However, current research describes osteoarthritis as a dynamic process involving tissue damage and repair that affects all structures in a joint3,4, including remodelling of subchondral bone, subchondral sclerosis, joint instability…

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I-Search Paper: Health Benefits Of Distance Running

I-Search Paper My smile lights up the room as I step on the scale and watch the scale number dwindle. My menu for the day consists of colorful food, not my past plate of browns and yellows. A feeling of serenity washes over me. I cannot help but be impressed with myself and how far I have come in the past year. My whole disposition about life has brightened and to think it is because of running. I have made an effort to change my lifestyle, particularly through running. As I find myself progressing…

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