Dr. Ann Repka
Bio 203-Z501
3/1/15
Case Study 1: Margaret
Osteopenia is a condition where bone mineral density is low.
Simple columnar epithelium with microvilli.
It is of a single layer of columnar epithelial cells (each of which is taller than it is wide) on top of a basement membrane. The nuclei of each cell form a row along the side closest to the basement membrane.
Tight junctions would be damaged. Tight junctions create barriers that prevent molecules passing through the membrane. They play a crucial role in permeability.
Connective Tissue.
Osteoclasts - dissolve bone; Osteoblasts - Form/build new bone and control mineral and calcium deposition; Lining Cells - regulate passage of calcium in and out of bone and respond to …show more content…
The calcium in bones is in the form of hydroxyapatite (a salt made up of phosphate ions and calcium ions) which help with certain metabolic reactions and help form blood clots.
Fibroblasts
The parathyroid hormone (PTH), 1,25(OH)2D (the active form of vitamin D), and calcitonin help regulate blood calcium levels. The thyroid gland secretes calcitonin which inhibits osteoclasts and stimulates osteoblasts, which decreases blood calcium levels. Hypocalcemia stimulates the parathyroid glands and they secrete the parathyroid hormone which inhibits osteoblasts, stimulates osteoclasts, and decreases the calcium output in the kidneys by stimulating the synthesis of vitamin D which promotes calcium absorption by the small intestines and that causes increased blood calcium levels.
Vitamin D is needed to regulate normal blood levels of phosphate and calcium, which are required for normal bone mineralization. The active form of vitamin D controls the transcription many gene codings for bone matrix proteins and calcium transporting proteins which directly relate to the roll Vitamin D plays in calcium transport and bone …show more content…
In her case it directly relates to the low levels of serum calcium and vitamin D.
They are low because the osteoblasts that build bone are being inhibited and osteoclasts that dissolve bone are being stimulated and the calcium and vitamin D aren't able to be absorbed into the blood
Her body is trying to increase calcium levels by eventually promoting calcium absorption in the small intestines, but if the celiac disease is causing malabsorption in the intestinal wall and calcium is at a dead end and cant be absorbed, then the process of the calcium homeostasis are continually active which is resulting in a nonstop decrease of bone density because of the increased activity of osteoclasts.
They are very similar, but not exactly alike. Osteopenia is like the forerunner of osteoporosis. Osteopenia results in low bone mineral density, but the bone mineral density level isn't low enough to be considered osteoporosis. Osteoporosis is more painful and can be severe enough to cause bones to break just from normal daily activities and functions such as standing up, or even coughing.
Works