Edward Jenner discovered that milkmaids who had been infected by the disease of cowpox, a similar but not as harmful disease, seemed to be immune to smallpox. The observation led him to experiment and later invent the smallpox vaccine. He published his findings in 1748. Clinical care knew that the vaccine had worked, but they didn’t know why it worked. The reasoning was later found in the 1800’s. A French scientist discovered that germs were a part of smallpox and after there were enough antibodies to kill one germ, smallpox would be cured within the body. 30 years after Jenner died, the smallpox vaccine was a regular practice for preventing the disease. Edward Jenner is known for developing the smallpox vaccine, which played a major role in medicine. He is often referred to as the "Father of Immunology." His work laid the foundation for the spread of smallpox, a deadly disease. Smallpox has a long and devastating history. Smallpox is known as one of the most harmful diseases spreading in epidemic form throughout many countries since the earliest times, leaving death and scarring in its wake. Some symptoms of smallpox include high fever, vomiting, mouth sores, and fluid-filled lesions on the whole body. Death was not long after that