Wound Healing Case Study

Words: 953
Pages: 4
Open Document
1. 7. Growth Factors and Cytokines in Wound Healing
The wound healing process begins immediately followed by injury. The close control of degradative and regenerative processes of the wound repair requires numerous cell types and complex interactions between multiple biochemical cascades. Growth factors released in the traumatized area to promote cell migration into the wound area (chemotaxis), stimulate the growth of epithelial cells, and fibroblasts. Which thereby, initiate the formation of new blood vessels stimulates matrix formation and remodeling of the affected region (Komarcevic, 2000).
Growth factor plays a major role in the affect the inflammatory, proliferation and migratory phases of wound healing (Dijke et al., 1989). There are …show more content…
It was reported to be a potent mitogen and maturation factor for epidermal cells (Ullrich et al., 1990). EGF is present in body fluid, and it is expressed at very low concentration in normal tissue. EGF induces epithelial cells to migrate, divide, and differentiate. Receptors for this very influential growth factor have been localized on the migrating and proliferating epithelial tips present at the wound edges and on epithelial islands arising from the remnant epidermal appendages (Wenczak et al., 1992). EGF and TGF-α are closely related (35 % homology) and possess very similar activities. Wound macrophages contain significant amounts of TGF-α that add to the significance of this cell in the initial tissue response to injury. The main function of these growth factors appears to be on granulation tissue development, with epidermal re-growth and modulation of angiogenesis being unique features of TGF-α activity (Whitman et al., …show more content…
1. 7. 4. Keratinocyte growth factor (KGF)
KGF is a potent factor in variety of epithelial cells. KGF and TNF- α stimulates epithelial cell migration, which is thought to occur indirectly via the expression of KGF (Brauchle et al., 1994). The KGF induces reepithelialization within hours of injury. The cell-cell and cell–substratum interaction was followed by migration of keratinocytes over the extracellular matrix (ECM). When complete wound closure occurs, keratinocytes undergo stratification and differentiation to restore the barrier.
1. 7. 5. Platelet-derived growth factor
Show More

Related Documents: Wound Healing Case Study

Wound Healing: A Case Study

WOUND HEALING Three influences of inflammation on wound healing. A wound has to go through four stages to heal; hemostasis, inflammation, proliferation, and remodeling, with each phase being precise, in the proper order and time. If there is any abnormal interference in any of these stages wound healing will not occur. Hemostasis is stage one where blood is limited, and protein (fibrin) is produced to form a clot, where the release of pro-inflammatory cytokines becomes the…

Words 705 - Pages 3

Wound Healing Case Study

The aim of this assignment is to discuss and explore the process of wound healing by secondary intention. The assignment will also look at the wound Mrs Wallis gained on her leg, and discuss what it would look like after seventy two hours to the health care worker. The skin is the most complex yet largest organ in weight on the body and belongs to the Integumentary system (BBC 2014). The main layers of the skin consist of the epidermis, dermis and the hypodermis. Together these make up the structure…

Words 764 - Pages 4

Wound Healing: A Case Study

The Role of Nutritional Interventions with Wound Healing Clinical Question One common issue faced by nurses in healthcare is wounds. The treatment of pressure ulcers alone cost approximately $11 billion dollars per year in the United States (Sernekos, 2013). The estimated annual cost to treat pressure ulcers in the United Kingdom is approximately £1.4 to £2.1 billion pounds (Siang Choo, Hayter, & Watson, 2013). Pressure ulcers wounds are important to nursing practice because pressure ulcers often…

Words 549 - Pages 3

Malnutrition In Acute Care

facilities by taking the process of wound healing as an example to achieve that goal and make nutritional care more recognizable by the hospitals. Many studies have shown different effects that malnutrition can cause during this process. The analysis of the patients in multiple acute care facilities revealed that majority of them are insufficiently nourished or malnourished (Lavrinec, Mikus, Zajec, & Lavrinec, 2007). In malnourished patients, wounds were healing slowly and the risk of development…

Words 1091 - Pages 5

Infection: The Differences In Animal Bites

circulated. But is this really true? The idea may have originally come from the fact that there were studies showing that human bites have a higher chance of becoming infected than most animal bites, including those caused by dogs. While contemporary scientists are not sure where this information came into contact with the public, they are all in agreement that it is simply untrue. Modern studies about infection rates in animal bites show that it is pretty even across the board as to whether or not…

Words 485 - Pages 2

Maxcis Insurance Case

Castle of Maxcis Insurance Company referred this file for medical case management. Instructions were given to meet with Robert Kise and assist with coordination of appropriate and related medical care, and identify needs to facilitate recovery. INTERVIEW SETTING On 10/19/16 I met Mr. Kise at the office of Dr. Lewis Infectious Disease. Mr. Kise arrived alone to the appointment. He is alert and oriented and willing to work with a nurse case manager. Mr. Kise is wearing a cam boot to the left leg. MEDICAL…

Words 883 - Pages 4

Extraarticular Ligament Healing Case Study

List the 3 stages of healing. 1. inflammation 2. proliferation 3. maturation/ remodeling PHASE 1 What are the common names for this phase? The common names for this phase (inflammation phase) are acute, subacute, and chronic inflammation. How long does this phase last? Acute phase: This phase last short time; usually it occurs from a few hours to some days. Subacute phase: It takes places after resolution of the rapid acute inflammation; typically during the first 24 hours after the injury.…

Words 1576 - Pages 7

House Literature Search Essay

question in PICO format For patients at high risk of getting pressure ulcers does the use of positioning methods reduce the future risk of getting pressure ulcers compared to not using positioning methods? 2. Below are abstracts from a number of studies that were retrieved when you did a literature search using the key word “pressure ulcer”. Below each indicate whether or not you would retrieve the article to use in answering your PICO questions along with the reason(s) you would or would not retrieve…

Words 5199 - Pages 21

Rn vs Bsn Essay

Beginning with the ADN, I believe she would be successful at contacting a home health agency to provide wound care and visits for dressing changes. She would be able to arrange for transportation home and be of assistance in helping the patient to schedule a physician office visit. I’m not sure due to a lack of education in public health awareness that the…

Words 1004 - Pages 5

Essay on Humans and Parasites

a much better grasp of healing and inhibiting bacterial infections and we no longer required the use of maggots to heal open wounds. Although, in 1989 there were findings that maggot therapy was superior in certain cases to antibiotic therapy for eradicating a bacterial infection. The first modern clinical studies of maggot therapy were started at the Veterans Affairs Medical Center in Long Beach, CA, and at the University of California, Irvine. The results of these studies showed that the use of…

Words 2064 - Pages 9