Coronary Heart Disease Research Paper

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Coronary heart disease (CHD) is a disease that varies dramatically on its progression and development depending on the diet, lifestyle and genetic factors of the individual. Atherosclerosis is the main process that causes CHD. Damage to the endothelial layer in the artery can be cause by several different things including high blood pressure etc. Low density lipoproteins (LDL’s) in the blood stream then enter the subendothelial layer through the damage of the endothelial layer and there they are oxidised. The LDL’s release cytokines into the bloodstream which signals monocytes migrate to the area of damage and into the subendothelial space. These monocytes then differentiate into macrophages and then bind to the LDL’s producing foam cells.

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