Lung Injury Lab Report

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Abstract

Background
Lung injury is a severe complication after thoracic surgical procedures. We hypothesized that application of continuous positive airway pressure (CPAP) to a non-ventilated lung would prevent alveolar hypoxia and blood flow shift from the non-ventilated to the ventilated lung, thereby attenuating lung injury after one-lung ventilation (OLV).
Methods
Rats were assigned to one of two ventilation protocol groups: OLV and CPAP groups. Rats in the OLV group received 240 minutes of OLV following 240 minutes of two-lung reventilation. Rats in the CPAP group received CPAP (5 cm H2O with 100% O2) to the non-ventilated lung during OLV. Inflammatory cytokines in both lungs were quantified after 240 minutes of OLV or 240 minutes of two-lung reventilation. We investigated pulmonary blood flow during OLV and the pulmonary wet-to-dry ratio and malondialdehyde levels after two-lung reventilation.
Results
Application of CPAP decreased the levels of interleukin-6, CXC chemokine ligand-1, and CC chemokine ligand-2 in both lungs after 240 minutes of OLV. After 240 minutes of two-lung reventilation, CXC chemokine ligand-1 in the non-ventilated lung and CC …show more content…
Alveolar hypoxia is known to cause lung inflammation.{Frohlich:2013fe} Recently, we demonstrated that atelectasis causes alveolar hypoxia-induced inflammatory responses, including CXCL-1 secretion from lung epithelial cells, through activation of nuclear factor-κB. {Tojo:2015wu} Therefore, it is possible that improvement of alveolar hypoxia by CPAP might lead to attenuation of hypoxia-induced inflammatory responses. On the other hand, static inflation or ventilation is reportedly protective against pulmonary ischemia-reperfusion injury, irrespective of the oxygen concentration of ventilation air.{Kao:2004gs} Therefore, the prevention of complete collapse during OLV might contribute to the protective effects of

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