Pancreatitis Research Paper

The pancreas is an organ that makes hormones and enzymes to help digestion. The pancreas is composed of two distinct compartments, the exocrine compartment (acinar cells) that produce hormones, and endocrine compartment (islets of Langerhans) that produce digestive enzymes [3]. Pancreatitis is a major pancreatic disorder, targeting the acinar cells, that has a high morbidity and mortality rate. Pancreatitis is inflammation of the exocrine compartment of pancreas, and pancreatic damage arises subsequent to activation of digestive enzymes within acinar cells before they are secreted into the duodenum [3-6]. Normally, these enzymes are maintained in an inactive state until they are secreted into the duodenum [6].The pathophysiology cause of pancreatitis …show more content…
Acute pancreatitis develops in response to sudden premature activation of acinar cells. Chronic pancreatitis is a long-standing inflammation of the pancreas [7-8]. Pancreatic injury will lead to acute pancreatitis, there are 4 stages for developing pancreatitis, initiation, activation of pancreatic stellate cells (PSC), inflammation, and regeneration. The first step in the process, initiation of pancreatitis, is thought to be the result of an injury by pathophysiological cause of pancreatitis [8]. Normally stellate cells are quiescent and injury may cause activation of pancreatic stellate cells, that can lead to inflammation of pancreas as aforementioned above [8-10]. Repeated attacks of AC my induce Chronic pancreatitis and CP is a major risk factor to PDAC and both are correlated with exocrine function [11]. Chronic pancreatitis can lead to irreversible pancreatic damage and leads to depletion in exocrine function of pancreas and may culminate reprogramming. While a number of genetic mutations have been associated with pancreatitis, but the mechanism of risk has not been well distinguished, and understanding of the epigenetic factors to the disease is

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