Over-consumption of alcohol can lead to the death of brain cells, which can lead to brain disorders as well as a lowered level of mental or physical function. Liver damage from alcohol can result in a liver transplant depending on how the liver was affected by the alcohol. You can also develop a tolerance to alcohol. This means that the body becomes accustomed to high doses of alcohol, which makes it possible for drinkers to consume more amounts of alcohol. Tolerance to alcohol can lead to dependence or addiction. (The