Deception is largely based on the assumption that if subjects knew the true nature of the experiment then they would not act naturally and hence contaminate the results. (Lesko 2012). According to California State University deception happens, while exploring your area of interest may require misleading or not completely informing your subjects about the true nature of your research.
The Centers for Disease Control and Prevention, says (in 1932, the Public Health Service, working with the Tuskegee Institute, began a study to record the natural history of syphilis in hopes of justifying treatment programs for blacks. It was called the "Tuskegee Study of Untreated Syphilis in the Negro Male)." With the Tuskegee experiment it was misleading of human research subjects. Federal regulations prohibit the use of deceptive techniques that place subjects at greater than minimal risk. With the Tuskegee experiment it was misleading of human research