This disease affects twenty-five million Americans and is more common in women. Also, juvenile hypothyroidism may lead to retarded mental and physical development. However, it is most commonly seen in adults. Hypothyroidism is characterized by a sluggish metabolic rate and in extreme cases myxedema, slowing down of mental and physical activity. The symptoms may include sleepiness, loss of memory, coarse skin, goiter, depression, increase in weight, sensitivity to cold, and potential hair loss. However, the most severe cases occur in children with congenital hypothyroidism. Because thyroid hormone is vital for normal growth and neural development, a major reduction in this hormone will lead to cretinism, dwarfism and mental retardation. Unfortunately, if this disease is not detected early the developmental changes will be permanent. There is a myriad of causes of this condition ranging from primary failure of the thyroid gland to inadequate supply of iodine in the diet. Fortunately, all hypothyroidism may be treated with oral medication to replace the hormone; however, dosing adjustments will be required to find the ideal dose for each